Benzaldehyde → HCID 10977131, compound

Temperature

70 °C

Metal sodium (303 mg) was added to dry 2-propanol (30 mL), and the mixture was stirred at 70° C. After the sodium was dissolved, benzaldehyde (1.0 g) was added to the solution at 0° C., 4-bromobutyltriphenylphosphonium bromide (5.4 g) was then added, and the mixture was gradually warmed to room temperature. After 5 hours, the reaction mixture was concentrated under reduced pressure, ethyl acetate was added to the residue, and the resultant mixture was washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was then purified by column chromatography on silica gel (hexane) to obtain the title compound.

1. temperaturethe mixture was gradually warmed to room temperature
2. concentrationthe reaction mixture was concentrated under reduced pressure, ethyl acetate
3. additionwas added to the residue
4. washthe resultant mixture was washed with water and saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue was then purified by column chromatography on silica gel (hexane)

ORD record

ord-9d2367d9d44b456fac0bc0d0bb752681

Source dataset

uspto-grants-2003_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06552188B2