Hydrochloric Acid → 2-chloro-N-(5-methoxy-2-methylphenyl)acetamide

HRID 1267921ノート

反応式

HRID 1267921 の反応式
[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:3]=1[NH2:4].C(N(C(C)C)CC)(C)C.[Cl:20][CH2:21][C:22](Cl)=[O:23].Cl>O1CCCC1>[Cl:20][CH2:21][C:22]([NH:4][C:3]1[CH:5]=[C:6]([O:9][CH3:10])[CH:7]=[CH:8][C:2]=1[CH3:1])=[O:23]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 995005-Methoxy-o-toluidine

生成物 1

HCID 11328892-chloro-N-(5-methoxy-2-methylphenyl)acetamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-methyl-5-methoxyaniline (4.7 g) in tetrahydrofuran (50 ml), under nitrogen, was added diisopropylethylamine (12.6 ml) followed by dropwise addition of chloroacetyl chloride (2.7 ml) and the mixture stirred under nitrogen for 27 hours. The solution was poured into 2M aqueous hydrochloric acid (150 ml), extracted into diethyl ether (3×150 ml), washed with brine, dried (MgSO4), and concentrated to give the sub-title compound as a brown oil (5.15 g).

後処理

  1. extractionextracted into diethyl ether (3×150 ml)
  2. washwashed with brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-36a1ed5f78f94422bbb65456f266ec6b
出典データセット
uspto-grants-2003_04
特許番号
US06555541B1

反応ノート

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