反应详情

101 μl (1.00 mmol) of 4-methylmorpholine are added to a solution of 212 mg (1.00 mmol) of 2-(4-aminophenyl)isothiazolidine 1,1-dioxide, 276 mg (1.00 mmol) of 2-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-pentanoic acid, 192 mg (1.00 mmol) of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (DAPECI) and 135 mg (1.00 mmol) of hydroxybenzotriazole hydrate (HOBt) in 1 ml of DMF, and the mixture is stirred at room temperature for 24 hours. The reaction mixture is introduced into water, and the precipitate is filtered off, giving 2-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-N-[4-(1,1-dioxoisothiazolidin-2-yl)phenyl]valeramide as a colourless solid; ESI 471.

1. filtrationthe precipitate is filtered off