Hydrochloric Acid → HCID 131726317, compound

HRID 1268827Notes

Reaction equation

HRID 1268827 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][CH:10]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][CH2:23][CH2:22][S:21]3(=[O:26])=[O:25])=[C:16]([CH3:27])[CH:15]=2)=[O:12])[CH:6]=[CH:7][CH:8]=1.[ClH:34]>CC(O)C>[ClH:34].[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][CH:10]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][CH2:23][CH2:22][S:21]3(=[O:26])=[O:25])=[C:16]([CH3:27])[CH:15]=2)=[O:12])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10183315HCID 10183315, compound

Product 1

HCID 131726317HCID 131726317, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

137 mg (0.295 mmol) of 2-(3-aminomethylphenylamino)-N-[4-(1,1-dioxoisothiazolidin-2-yl)-3-methylphenyl]-2-phenylacetamide are dissolved in 2.95 ml (0.295 mmol) of 0.1 N HCl in 2-propanol, and the mixture is left to stand at room temperature for 2 hours. The reaction mixture is evaporated and subsequently lyophilised, giving 2-(3-aminomethylphenylamino)-N-[4-(1,1-dioxoisothiazolidin-2-yl)-3-methylphenyl]-2-phenylacetamide, hydrochloride (“BB”) as a colourless solid; ESI 465.

Workup

  1. waitthe mixture is left
  2. customThe reaction mixture is evaporated

Sources & evidence

ORD record
ord-14741da2dd63471f8cb175914a0b120b
Source dataset
uspto-grants-2007_04
Patent number
US07199133B2

Reaction notes

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