2-(Trimethylsilyl)ethanol → HCID 91051553, compound

HRID 1268953Notes

Reaction equation

[C:1]([C:5]1[CH:23]=[CH:22][C:8]([O:9][C@@H:10]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[C:11]([OH:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(Cl)(=O)C(Cl)=O.[CH3:30][Si:31]([CH3:36])([CH3:35])[CH2:32][CH2:33]O>>[C:1]([C:5]1[CH:23]=[CH:22][C:8]([O:9][C@@H:10]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=2)[C:11]([O:13][CH2:33][CH2:32][Si:31]([CH3:36])([CH3:35])[CH3:30])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 3

HCID 180132-(Trimethylsilyl)ethanol

HCID 65578Oxalyl chloride

HCID 10969049HCID 10969049, compound

Product 1

HCID 91051553HCID 91051553, compound

Procedure

The target compound (16.0 g) was obtained as colorless crystals by carrying out the reaction and the post-treatment according to Reference example 20(e) using the above carboxylic acid (13.3 g), oxalyl chloride (18.45 ml) and 2-trimethylsilylethanol (30.3 ml).

Workup

customthe reaction

Sources & evidence

ORD record: ord-67969f1331ef4e4185b62e599d773d21
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199139B2

Reaction notes

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