Isopropylamine → HCID 18449223, compound

HRID 1270161Notes

Reaction equation

HRID 1270161 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[C:7](Cl)[C:8]3[N:9]2[C:12]([O:15][CH3:16])=[N:13][N:14]=3)=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].[CH:23]([NH2:26])([CH3:25])[CH3:24]>CN(C=O)C.CCOC(C)=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[C:7]([NH:26][CH:23]([CH3:25])[CH3:24])[C:8]3[N:9]2[C:12]([O:15][CH3:16])=[N:13][N:14]=3)=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 6363IsopropylamineHCID 516892Sodium BicarbonateHCID 184491838-Bromo-4-chloro-1-methoxy[1,2,4]triazolo[4,3-a]quinoxaline

Product 1

HCID 18449223HCID 18449223, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
23 °C

Procedure

To a solution of 8-bromo-4-chloro-1-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline (2.0 g) in DMF (50 mL) was added solid sodium bicarbonate (1.1 g) and isopropylamine (0.82 mL). The resulting mixture was stirred at 23° C. for 18 hrs. and then diluted with EtOAc. The mixture was washed sequentially with water and brine, and then dried over sodium sulfate. Concentration afforded (8-bromo-1-methoxy-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl)-isopropyl-amine as a light yellow solid. MS (M+H)+=337.3.

Workup

  1. washThe mixture was washed sequentially with water and brine
  2. dry with materialdried over sodium sulfate
  3. concentrationConcentration

Sources & evidence

ORD record
ord-60618df52c874dbbb982d96dd7902e4e
Source dataset
uspto-grants-2007_04
Patent number
US07202245B2

Reaction notes

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