Pyrazole → 1-Phenylpyrazole

HRID 1270693Notes

Reaction equation

HRID 1270693 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:8]1[CH:12]=[CH:11][CH:10]=[N:9]1>C(#N)C>[C:2]1([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 1048PyrazoleHCID 7961Bromobenzene

Product 1

HCID 707691-Phenylpyrazole

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Operating protocol A (82° C., 24 hours) was followed using 120.8 mg of Chxn-Thio-Al (0.4 mmoles), 211 μl of bromobenzene (2 mmoles), 204 mg of pyrazole (3 mmoles) and 1.2 ml of acetonitrile.

Workup

  1. customA (82° C., 24 hours)

Sources & evidence

ORD record
ord-7a49e189cc1d4fc0a2513ee1132f886a
Source dataset
uspto-grants-2007_04
Patent number
US07202367B2

Reaction notes

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