O-Cresol → Bis(2-methylphenyl) ether

HRID 1270706Notes

Reaction equation

HRID 1270706 reaction equation
[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.IC1C=CC=CC=1.I[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23].C(#N)C>CN(C=O)C>[C:1]1([CH3:8])[C:6]([O:7][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 335O-CresolHCID 51282-IodotolueneHCID 6342AcetonitrileHCID 11575Iodobenzene

Product 1

HCID 78462Bis(2-methylphenyl) ether

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Example 3.1 was repeated, replacing the phenol with 206 μl of o-cresol (2 mmoles) and the iodobenzene with 383 μl of 2-iodotoluene (3 mmoles), the acetonitrile with DMF, and with the nucleophile and the arylation agent being added at the same time as the solvent.

Sources & evidence

ORD record
ord-d4139118a0e14521a2c0cffc395a74db
Source dataset
uspto-grants-2007_04
Patent number
US07202367B2

Reaction notes

Loading…