Tetrahydrofuran → HCID 18453527, compound

HRID 1271424Notes

Reaction equation

HRID 1271424 reaction equation
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]([CH2:8][O:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[N:13]2)=[CH:6][CH:5]=1)([O-])=O.C1COCC1>CO.[Pt](=O)=O>[N:12]1([CH2:11][CH2:10][O:9][CH2:8][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:18][CH:17]=2)[CH:16]=[CH:15][N:14]=[N:13]1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 184535171-[2-(4-nitro-benzyloxy)-ethyl]-1H-[1,2,3]triazole

Product 1

HCID 18453527HCID 18453527, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

1-[2-(4-Nitro-benzyloxy)-ethyl]-1H-[1,2,3]triazole (3.6 g, 14.5 mmol) and platinum dioxide (0.4 g) were suspended in methanol (30 ml) and THF (30 ml) and hydrogenated for 3 h at 42 mbar. After filtration and concentration 3 g (95%) 4-(2-[1,2,3]triazol-1-yl-ethoxymethyl)-phenylamine were obtained as beige solid.

Workup

  1. filtrationAfter filtration

Sources & evidence

ORD record
ord-299de1515b28463fa6e3ba83b5ad3a36
Source dataset
uspto-grants-2007_04
Patent number
US07205326B2

Reaction notes

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