Hydrochloric Acid → HCID 68829855, compound

HRID 1271443Notes

Reaction equation

HRID 1271443 reaction equation
[N:1]1([CH2:6][C@H:7]2[CH2:11][CH2:10][C@@H:9]([NH:12][CH2:13][C:14]([N:16]3[CH2:20][C@@H:19]([F:21])[CH2:18][C@H:17]3[C:22]#[N:23])=[O:15])[CH2:8]2)[CH:5]=[N:4][CH:3]=[N:2]1.[ClH:24]>CCOC(C)=O>[ClH:24].[N:1]1([CH2:6][C@H:7]2[CH2:11][CH2:10][C@@H:9]([NH:12][CH2:13][C:14]([N:16]3[CH2:20][C@@H:19]([F:21])[CH2:18][C@H:17]3[C:22]#[N:23])=[O:15])[CH2:8]2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11623906868771-57-7

Product 1

HCID 68829855HCID 68829855, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a stirred solution of Example 42 (250 mg, 0.80 mmol) in EtOAc (3 ml) was added a saturated solution of dry HCl in EtOAc (2 ml). This solution was stirred at RT for 30 min to result a white precipitate. The product was collected by filtration and dried under vacuum to give 279 mg of the product as a white solid; 1H NMR (D2O, 300 MHz) δ 1.41–1.62 (m, 2H), 1.75–1.87 (m, 2H), 2.02–2.17 (m, 2H), 2.27–2.74 (m, 4H), 3.67–4.20 (m, 4H), 4.41 (d, J=6.9 Hz, 2H), 5.00–5.15 (m, 1H), 5.43–5.60 (m, 1H), 8.52 (s, 1H), 9.27 (s, 1H).

Workup

  1. customto result a white precipitate
  2. filtrationThe product was collected by filtration
  3. customdried under vacuum

Sources & evidence

ORD record
ord-2aa92b10fc874d7faf01db62d8d29a08
Source dataset
uspto-grants-2007_04
Patent number
US07205323B2

Reaction notes

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