Hydrochloric Acid → HCID 68588179, compound

HRID 1271507Notes

Reaction equation

HRID 1271507 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][C:5]=1[O:16][C@H:17]1[CH2:26][CH2:25][C@@H:24]2[C@@H:19]([CH2:20][C@@H:21]([C:34]([OH:36])=[O:35])[N:22](C(OC(C)(C)C)=O)[CH2:23]2)[CH2:18]1)([OH:3])=[O:2].C(OCC)(=O)C.[ClH:43]>C(OCC)C>[ClH:43].[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:6][C:5]=1[O:16][C@H:17]1[CH2:26][CH2:25][C@@H:24]2[C@@H:19]([CH2:20][C@@H:21]([C:34]([OH:36])=[O:35])[NH:22][CH2:23]2)[CH2:18]1)([OH:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl Acetate2×HCID 68586368HCID 68586368, compound

Product 1

HCID 68588179HCID 68588179, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The material from step B (350 mg, 0.71 mmol) was treated with ethyl acetate saturated with hydrogen chloride (7 mL) for 4 hours at room temperature. The mixture was concentrated in vacuo to afford, after trituration with ethyl acetate and diethyl ether, the desired aminoacid (250 mg, 82%).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customto afford

Sources & evidence

ORD record
ord-047a611befbd44d39ed7828ff29dfb4e
Source dataset
uspto-grants-2007_04
Patent number
US07205313B2

Reaction notes

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