1-Phenylpiperazine → HCID 178456455, compound

HRID 1271601Notes

Reaction equation

HRID 1271601 reaction equation
[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[NH:11][C:10]([C:15]3[N:19]([CH3:20])[N:18]=[C:17]([O:21][CH2:22][C:23]([OH:25])=O)[CH:16]=3)=[N:9][C:8]=2[N:7]([CH2:26][CH:27]=[CH2:28])[C:5]1=[O:6])[CH:2]=[CH2:3].[C:29]1([N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>CN(C)C=O>[CH3:20][N:19]1[NH:18][C:17]([O:21][CH2:22][C:23]([N:38]2[CH2:39][CH2:40][N:35]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:36][CH2:37]2)=[O:25])=[CH:16]/[C:15]/1=[C:10]1\[N:11]=[C:12]2[C:13](=[O:14])[N:4]([CH2:1][CH:2]=[CH2:3])[C:5](=[O:6])[N:7]([CH2:26][CH:27]=[CH2:28])[C:8]2=[N:9]\1

Participants

6

Reactant 4

HCID 70961-PhenylpiperazineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 135610068HCID 135610068, compound

Product 1

HCID 178456455HCID 178456455, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Condensation of 2-[5-(1,3-diallyl-xanthin-8-yl)-1-methyl-pyrazol-3-yl)oxyacetic acid (0.5 mmol) and N-phenyl-piperazine (1.3 mmol) in the presence of EDCl (1.12 mmol) and HOBt (1.14 mmol) in anhydrous dimethylformamide afforded the desired product.

Sources & evidence

ORD record
ord-75dbb2d939874009ace5f28fa585cfb0
Source dataset
uspto-grants-2007_04
Patent number
US07205403B2

Reaction notes

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