反应详情

温度

-10 °C

Ethyl 3-amino-4,4,4-trifluorocrotonate (61.3 g, 33.1 mmol) was dissolved in dimethylformamide (47 ml) and stirred at −10 ° C. To this solution was slowly added 1,8-diazabicyclo [5.4.0]undec-7-ene (6.3 g, 41.4 mmol) and solution stirred for 0.5 hr. To this solution was slowly added a solution of 4-chloro-2-fluoro-5-methyl-6-nitro-N-phenoxycarbonylaniline (8.5 g) in dimethylformamide (25 ml) followed by stirring at ambient temperature for 14 hr. Solution was then heated to 80 ° C. and stirred at this temperature for 4 hr. Water was added and pH adjusted to 4 by addition of dilute hydrochloric acid. Product was extracted with ethyl acetate followed by evaporation of the solvent to afford the crude product (10.1 g) which was subjected to N-methylation as follows.

1. stirringstirred for 0.5 hr
2. stirringby stirring at ambient temperature for 14 hr
3. temperatureSolution was then heated to 80 ° C.
4. stirringstirred at this temperature for 4 hr
5. extractionProduct was extracted with ethyl acetate
6. customfollowed by evaporation of the solvent