Di-tert-butyl dicarbonate → HCID 69360303, compound

HRID 1272178Notes

Reaction equation

HRID 1272178 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][CH:15]=[C:14](F)[CH:13]=3)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:23]([O:25]C1C=C2C(N3C(=C2)C(=O)NCC3C)=NC=1)[CH3:24].[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OC(OC(OC(C)(C)C)=O)=O)(C)(C)C>CN(C)C1C=CN=CC=1>[C:1]([O:5][C:6]([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C:10](=[CH:11][C:12]3[C:17]2=[N:16][CH:15]=[C:14]([O:25][CH2:23][CH3:24])[CH:13]=3)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 90495Di-tert-butyl dicarbonateHCID 18455988HCID 18455988, compoundHCID 21226445Aluminium lithium hydrideHCID 69357759HCID 69357759, compound

Product 1

HCID 69360303HCID 69360303, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

This compound was prepared in analogy to Example 1, intermediate h) from 7-ethoxy-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one and lithium aluminium hydride and protection of the free amine with di-tert-butyl-dicarbonate and 4-(dimethylamino)pyridine.

Sources & evidence

ORD record
ord-e5c7fdb207e345fca1bea6bef1614321
Source dataset
uspto-grants-2007_04
Patent number
US07208494B2

Reaction notes

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