Hydrochloric Acid → HCID 18456017, compound

HRID 1272337Notes

Reaction equation

HRID 1272337 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:6][C:7]1([CH3:32])[CH:11](O)[C:10]2[C:13]([CH3:31])=[C:14]([N:19]3[CH:24]=[CH:23][N:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:21]=[CH:20]3)[C:15]([CH3:18])=[C:16]([CH3:17])[C:9]=2[O:8]1.[ClH:33]>C(OCC)(=O)C>[ClH:33].[CH3:6][C:7]1([CH3:32])[CH:11]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[C:10]2[C:13]([CH3:31])=[C:14]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:21][CH2:20]3)[C:15]([CH3:18])=[C:16]([CH3:17])[C:9]=2[O:8]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31268PyrrolidineHCID 22935616HCID 22935616, compound

Product 1

HCID 18456017HCID 18456017, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using pyrrolidine and 2,2,4,6,7-pentamethyl-5-(4-phenyl pyrazine-1-yl)-2,3-dihydro-benzofuran-3-ol obtained in Reference Example 30, the free base was obtained in the same manner as in Example 57. The free base was treated with a 4N hydrogenchloride in ethyl acetate (10 ml) to obtain the title compound. Yield 80%. Amorphous powder.

Workup

  1. customobtained in Reference Example 30
  2. customthe free base was obtained in the same manner as in Example 57

Sources & evidence

ORD record
ord-aa6015307b9349638c79f48d3a151a0f
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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