Hydrochloric Acid → HCID 18456050, compound

HRID 1272351Notes

Reaction equation

HRID 1272351 reaction equation
[CH2:1]([Cl:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C:10]1([CH3:34])[CH:14]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[C:13]2[C:21]([CH3:33])=[C:22]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[C:23]([CH3:26])=[C:24]([CH3:25])[C:12]=2[O:11]1.[ClH:35]>C(OCC)(=O)C>[ClH:8].[ClH:35].[CH2:1]([N:30]1[CH2:31][CH2:32][N:27]([C:22]2[C:23]([CH3:26])=[C:24]([CH3:25])[C:12]3[O:11][C:10]([CH3:34])([CH3:9])[CH:14]([N:15]4[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]4)[C:13]=3[C:21]=2[CH3:33])[CH2:28][CH2:29]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7503Benzyl ChlorideHCID 22935611HCID 22935611, compound

Product 1

HCID 18456050HCID 18456050, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using Benzyl chloride and (2,2,4,6,7-pentamethyl-3-piperidino-2,3-dihydro-1-benzofuran-5-yl)piperazine obtained in Example 152, the free base was obtained in the same manner as in Example 2. The free base was treated with a 4 N hydrogenchloride in ethyl acetate solution (10 ml) to obtain the title compound. Yield 64% Amorphous powder.

Workup

  1. customthe free base was obtained in the same manner as in Example 2

Sources & evidence

ORD record
ord-b7753cbd33af46f1b7cbd34c82489e53
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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