反应详情

The starting material is prepared as follows: The mixture of 23.5 g of 4- aminopyridine, 38.5 g of cis-1,2-cyclohexanedicarboxylic acid anhydride and 400 ml of xylene is refluxed for 42 hours while stirring and separating the water formed. After the first half-hour, and after 18 hours, 1 ml of methane sulfonic acid is added to the mixture. It is filtered hot, the crystals formed after cooling are filtered off and recrystallized from isopropanol, to yield the 2-(4-pyridyl)-hexahydroisoindole-1,3-dione melting at 165°-168°.

1. customThe starting material is prepared
2. temperatureis refluxed for 42 hours
3. customseparating the water
4. customformed
5. filtrationIt is filtered hot
6. customthe crystals formed
7. temperatureafter cooling
8. filtrationare filtered off
9. customrecrystallized from isopropanol