Indomethacin → HCID 178487188, compound

HRID 1273498Notes

Reaction equation

HRID 1273498 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N#Cc1ccc(Cl)c(N)c1>CN(C)C=O.Cc1cccc(C)n1.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>COc1ccc2c(c1)c(CC(=O)Nc1cc(C#N)ccc1Cl)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 1044643-Amino-4-chlorobenzonitrile

Product 1

HCID 178487188HCID 178487188, compoundYield 0.67%

Reagents, catalysts & solvents 3

HCID 79372,6-LutidineReagentHCID 2724699PyBOPReagentHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-218ec0c190ec4a8bb4c91edd88e19b8b
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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