Indomethacin → HCID 178487189, compound

HRID 1273608Notes

Reaction equation

HRID 1273608 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.Cc1cc([N+](=O)[O-])ccc1N>CCN(C(C)C)C(C)C.CN(C)C=O.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>COc1ccc2c(c1)c(CC(=O)Nc1ccc([N+](=O)[O-])cc1C)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 74412-Methyl-4-nitroaniline

Product 1

HCID 178487189HCID 178487189, compoundYield 3.77%

Reagents, catalysts & solvents 3

HCID 81531DiisopropylethylamineReagentHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideReagentHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-92c4a27008584b11b8a56fe82268924a
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

Loading…