Indomethacin → HCID 178487185, compound

HRID 1273822Notes

Reaction equation

HRID 1273822 reaction equation
CC(C)c1cccc(C(C)C)c1N.COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1>CN(C)C=O.Cc1cccc(C)n1.O=P(Cl)(c1ccccc1)c1ccccc1>COc1ccc2c(c1)c(CC(=O)Nc1c(C(C)C)cccc1C(C)C)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 32484Diisopropylaniline

Product 1

HCID 178487185HCID 178487185, compoundYield 31.29%

Reagents, catalysts & solvents 3

HCID 79372,6-LutidineReagentHCID 73910Diphenylphosphinic chlorideReagentHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-873b44e54edc4a31b62c4d7d7e75b0b3
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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