Indomethacin → HCID 178487185, compound

HRID 1273834Notes

Reaction equation

HRID 1273834 reaction equation
CC(C)c1cccc(C(C)C)c1N.COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1>CCOC(=O)C(C#N)=N[O+]=C(N(C)C)N(C)C.CN(C)C=O.Cc1cccc(C)n1.F[P-](F)(F)(F)(F)F>COc1ccc2c(c1)c(CC(=O)Nc1c(C(C)C)cccc1C(C)C)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 32484Diisopropylaniline

Product 1

HCID 178487185HCID 178487185, compoundYield 43.57%

Reagents, catalysts & solvents 3

HCID 79372,6-LutidineReagentHCID 573489556-Cyano-N,N,2-trimethyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-iminium hexafluorophosphateReagentHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-8ea9e9f6f3fd4943a302e44ba3690076
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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