反应详情

Dimethylamine hydrochloride (1.74 g) is dissolved in absolute methanol (18 ml) and sodium methoxide (813 mg) is added thereto. To the solution are added a solution of the product of the above (1), (1.1 g) in tetrahydrofuran (10 ml) and sodium cyanoborohydride (1 g). The mixture is stirred at room temperature overnight and evaporated after addition of an aqueous solution (4 ml) of sodium hydroxide. The residue is extracted with ether after addition of water and a 10% aqueous solution of sodium hydroxide. The extract is condensed to give the title compound as an oil (1.10 g). The oil is treated with L-tartaric acid (443 mg) in ethanol to give the tartrate (750 mg) melting at 172°-177° C. (decomp.).

1. customevaporated
2. additionafter addition of an aqueous solution (4 ml) of sodium hydroxide
3. extractionThe residue is extracted with ether
4. additionafter addition of water
5. customcondensed