1-Phenylpiperazine → HCID 22117308, compound

HRID 1275562Notes

Reaction equation

HRID 1275562 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[C:7]=1C.[C:21]1([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>>[C:21]1([N:27]2[CH2:32][CH2:31][N:30]([CH2:2][CH2:3][CH2:4][S:5][C:6]3[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]4[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=4)[CH:7]=3)[CH2:29][CH2:28]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 70961-PhenylpiperazineHCID 11430Potassium CarbonateHCID 221173024-(3-Chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine

Product 1

HCID 22117308HCID 22117308, compoundYield 79%

Procedure

According to the procedure indicated in Example 7, reaction of 4-(3-chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine with 1-phenylpiperazine and potassium carbonate and subsequent chromatography on silica gel gives, after crystallization from diisopropyl ether, the title compound; m.p. from 210° C. (dec.); yield 79% of theory.

Workup

  1. customgives
  2. customafter crystallization from diisopropyl ether

Sources & evidence

ORD record
ord-33eab2c9418243e59a6bc251e731125e
Source dataset
uspto-grants-2000_12
Patent number
US06162809

Reaction notes

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