Hydrochloric Acid → HCID 22480362, compound

HRID 1275718Notes

Reaction equation

HRID 1275718 reaction equation
[C:1]([C:4]1[O:8][C:7]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:6][CH:5]=1)([OH:3])=[O:2].CC(C)([O-])C.[K+].[Cl:24][C:25]1[N:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][N:26]=1.Cl>CN(C=O)C>[ClH:24].[C:1]([C:4]1[O:8][C:7]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([C:25]3[N:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][N:26]=3)[N:10]=2)=[CH:6][CH:5]=1)([OH:3])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 27739122-Chloro-4-(trifluoromethyl)pyrimidineHCID 10198473HCID 10198473, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 22480362HCID 22480362, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

1.3 g (5.7 mmol) of 3-(5-carboxy-2-furyl)indazole together with 1.3 g (11.4 mmol) of potassium tert-butoxide were dissolved in 5 ml of dry DMF and admixed with 2-chloro-4-trifluoromethylpyrimidine dissolved in 5 ml of DMF. The mixture was stirred at 60° C. the hydrochloride was precipitated from the aqueous phase by addition of 1N hydrochloric acid. This gave 420 mg (25%) of the title compound. m.p.: 258-261° C.

Workup

  1. customwas precipitated from the aqueous phase by addition of 1N hydrochloric acid

Sources & evidence

ORD record
ord-2c0137cedf85401fa753520fffab9a54
Source dataset
uspto-grants-2000_12
Patent number
US06162819

Reaction notes

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