Hydrochloric Acid → HCID 22115898, compound

HRID 1276283Notes

Reaction equation

HRID 1276283 reaction equation
[Sn](Cl)(Cl)(Cl)Cl.[CH3:6][O:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([O:16][CH3:17])[CH:9]=1.[Cl:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23](Cl)=[O:24].Cl>C1C=CC=CC=1>[CH3:17][O:16][C:10]1[CH:9]=[C:8]([O:7][CH3:6])[CH:13]=[C:12]([O:14][CH3:15])[C:11]=1[C:23]([CH2:22][CH2:21][CH2:20][CH2:19][Cl:18])=[O:24]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 24287Tin tetrachlorideHCID 693011,3,5-TrimethoxybenzeneHCID 740895-Chlorovaleryl chloride

Product 1

HCID 22115898HCID 22115898, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

A solution of 91 g (0.384 mol) of tin tetrachloride in 112.5 ml of benzene is added over 1 h 30 min to a solution, maintained at about +5° C., of 50.4 g (0.3200 mol) of 1,3,5-trimethoxybenzene and 50.2 g (0.324 mol) of 5-chlorovaleryl chloride in 225 ml of benzene. The mixture is stirred overnight at room temperature and the reaction medium is poured into 325 ml of ice-cold water and 75 ml of 12N hydrochloric acid. The organic phase is separated out after settling has taken place, washed with water and dried over dry sodium sulphate.

Workup

  1. customThe organic phase is separated out after settling
  2. washwashed with water
  3. dry with materialdried over dry sodium sulphate

Sources & evidence

ORD record
ord-36e97376a08449d4971d5fc5b7920edb
Source dataset
uspto-grants-2000_12
Patent number
US06166035

Reaction notes

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