反应详情

To a stirred solution of 1,2,3,5,6,7-hexahydro-s-indacen-4-ylamine (77 grams) in tetrahydrofuran (1.5 L) and triethylamine (68.3 mL) was added triphosgene (43.9 grams) in one portion. The mixture was heated to reflux for 1/2 hour, then cooled to room temperature. The tetrahydrofuran was removed under reduced pressure, and the residue was taken up in pentane and filtered through a plug of silica gel. Removal of the pentane in vacuo afforded 80 grams of a white solid, m.p. 35.0-36.2° C.

1. temperatureThe mixture was heated
2. temperatureto reflux for 1/2 hour
3. customThe tetrahydrofuran was removed under reduced pressure
4. filtrationfiltered through a plug of silica gel
5. customRemoval of the pentane in vacuo