Hydrochloric Acid → 74697-35-1

HRID 1278255Notes

Reaction equation

HRID 1278255 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)=O)=[CH:5][C:4]=1[CH3:19].[C-]#[N:21].[K+].[C:23](=[O:26])([O-])O.[NH4+].[CH:28]([NH2:30])=[O:29].Cl>O>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]2([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=3)[NH:21][C:28](=[O:29])[NH:30][C:23]2=[O:26])=[CH:5][C:4]=1[CH3:19]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 713FormamideHCID 9032Potassium CyanideHCID 14013Ammonium BicarbonateHCID 19864229HCID 19864229, compound

Product 1

HCID 305819874697-35-1

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

34.5 Grams of 4,4'-dimethoxy-3-methylbenzophenone, 66.7 g of potassium cyanide and 232.2 g of ammonium hydrogencarbonate were heated to 120° C. together with 500 ml. of formamide and 100 ml. of water with stirring in an autoclave. After 72 hours, the reaction liquid was made acidic with concentrated hydrochloric acid, mixed with water and allowed to stand overnight. The precipitates thus formed were filtered out. The precipitates were dissolved in acetone, decolorized by active carbon under heating and recrystallized from hexane-acetone to obtain 22.7 g of 5-(4-methoxy-3-methylphenyl)-5-(4-methoxyphenyl)-hydantoin in the form of white crystals.

Workup

  1. customthe reaction liquid
  2. waitto stand overnight
  3. customThe precipitates thus
  4. customformed
  5. filtrationwere filtered out
  6. dissolutionThe precipitates were dissolved in acetone
  7. temperatureunder heating
  8. customrecrystallized from hexane-acetone

Sources & evidence

ORD record
ord-676d664ae2ee41bc83bcef77a20d934f
Source dataset
uspto-grants-1981_07
Patent number
US04281009

Reaction notes

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