Hydrochloric Acid → 1-(4-Amino-3'-fluoro[1,1'-biphenyl]-3-yl)ethanone

HRID 1278684Notes

Reaction equation

HRID 1278684 reaction equation
F[C:2]1C=C(B(O)O)C=CC=1.NC1C=CC(Br)=CC=1C#N.[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=2)=[CH:24][C:23]=1[C:35]#[N:36].C[Mg]Br.Cl.[C:41](=[O:44])([O-])[O-].[Na+].[Na+]>C1COCC1.C(OCC)(=O)C>[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=2)=[CH:24][C:23]=1[C:35]#[N:36].[NH2:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=2)=[CH:26][C:27]=1[C:41](=[O:44])[CH3:2]

Participants

10

Reactant 6

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 4297402-Amino-5-bromobenzonitrileHCID 27339863-Fluorophenylboronic acidHCID 220218944-Amino-3'-fluoro-[1,1'-biphenyl]-3-carbonitrileHCID 178418573HCID 178418573, compound

Product 2

HCID 220218911-(4-Amino-3'-fluoro[1,1'-biphenyl]-3-yl)ethanoneYield 43%HCID 220218944-Amino-3'-fluoro-[1,1'-biphenyl]-3-carbonitrile

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

4-Amino-3′-fluoro[1,1′-biphenyl]-3-carbonitrile was prepared from 3-fluorophenyl boronic acid and 2-amino-5-bromobenzonitrile according to procedure A. A solution of 4-amino-3′-fluoro[1,1′-biphenyl]-3-carbonitrile (6.65 g, 31.3 mmol) in anhydrous THF (100 mL) was treated drop wise at rt under nitrogen with methylmagnesium bromide (3.0 M in ether, 21 mL, 63 mmol). After addition, the reaction mixture was heated at gentle reflux for 1.5 hours, cooled to rt, and treated with 3N aqueous hydrogen chloride solution (30 mL). The mixture was heated at reflux for 3 hours, cooled to ambient temperature, and adjusted to pH 5-6 by addition of a saturated aqueous sodium carbonate solution. Ethyl acetate (100 mL) was added, organic layer was separated and aqueous layer was extracted with ethyl acetate (3×50 mL). The combined organic layers were dried (MgSO4) and evaporated. The residue was purified by a silica gel column chromatography (hexane:ethyl acetate/3:1) to afford 1-(4-amino-3′-fluoro[1,1′-biphenyl]-3-yl)ethanone (3.1 g, 43%): mp 156-157° C.

Workup

  1. additionAfter addition
  2. temperaturethe reaction mixture was heated
  3. temperatureat gentle reflux for 1.5 hours
  4. temperatureThe mixture was heated
  5. temperatureat reflux for 3 hours
  6. temperaturecooled to ambient temperature
  7. customorganic layer was separated
  8. extractionaqueous layer was extracted with ethyl acetate (3×50 mL)
  9. dry with materialThe combined organic layers were dried (MgSO4)
  10. customevaporated
  11. customThe residue was purified by a silica gel column chromatography (hexane:ethyl acetate/3:1)

Sources & evidence

ORD record
ord-7a0162917c7a4428bce9a66fbe037135
Source dataset
uspto-grants-2002_09
Patent number
US06444668B1

Reaction notes

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