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HRID1278920

反应详情

EQUATION

反应方程式

HRID 1278920 的结构方程式

REACTANTS

反应物

4
结构：O=O
HCID977

Oxygen

O2

结构：CCI
HCID6340

Ethane, iodo-

C2H5I

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：Cc1ccc(C#N)cc1O
HCID17750920

3-Hydroxy-4-methylbenzonitrile

C8H7NO

PRODUCTS

生成物

1
结构：CCOc1cc(C#N)ccc1C
HCID22476103

3-Ethoxy-4-methylbenzonitrile

C10H11NO

收率 72.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

10 g (75 mmol) of 4-methyl-3-hydroxybenzonitrile were deprotonated with 1 eq. of NaH in 100 ml of DMF and then ethylated on the oxygen with 112 mmol of iodoethane. 8.8 g of product were obtained.