Dimethylformamide → HCID 54053566, compound

HRID 1280325Notes

Reaction equation

HRID 1280325 reaction equation
CN(C)C=O.[C:6](Cl)(=O)[C:7]([Cl:9])=[O:8].[Cl:12][C:13]1[C:18]([Cl:19])=[C:17]([O:20][CH3:21])[CH:16]=[CH:15][C:14]=1CC(O)=O>ClCCl>[Cl:12][C:13]1[C:18]([Cl:19])=[C:17]([O:20][CH3:21])[CH:16]=[CH:15][C:14]=1[CH2:6][C:7]([Cl:9])=[O:8]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 19361980HCID 19361980, compound

Product 1

HCID 54053566HCID 54053566, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.5 ml of dimethylformamide and 60.9 g (0.48 mol) of oxalyl chloride were added to a solution of 37.3 g (0.16 mol) of 2,3-dichloro-4-methoxyphenylacetic acid in 0.5 l of dichloromethane. After evolution of gas had ceased (about 2 hours), the mixture was concentrated. The crude product was reacted further in the next step without any purification. Yield: quantitative.

Workup

  1. custom(about 2 hours)
  2. concentrationthe mixture was concentrated
  3. customThe crude product was reacted further in the next step without any purification

Sources & evidence

ORD record
ord-f4c3c8c2690b4f27a8a3b6ab38079074
Source dataset
uspto-grants-2002_09
Patent number
US06451734B1

Reaction notes

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