Potassium Iodide → HCID 18425026, compound

HRID 1280328Notes

Reaction equation

HRID 1280328 reaction equation
[Cl:1][C:2]1[C:3]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:20])[C:14]=2[Cl:21])=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Br[CH2:31][C:32]([O:34][CH3:35])=[O:33]>CN(C)C=O.O>[Cl:1][C:2]1[C:3]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:31][C:32]([O:34][CH3:35])=[O:33])=[C:15]([Cl:20])[C:14]=2[Cl:21])=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:9])[F:10]

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 18425029HCID 18425029, compound

Product 1

HCID 18425026HCID 18425026, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of 0.6 g (1.7 mmol) of 4-[(4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-yl)methyl]-2,3-dichlorophenol, 0.35 g (2.5 mmol) of potassium carbonate, 0.42 g (2.5 mmol) of potassium iodide and 0.39 g (2.5 mmol) of methyl bromoacetate in 30 ml of dimethylformamide was stirred for 16 hours and then admixed with 20 ml of water. The aqueous phase was subsequently extracted with 100 ml of diethyl ether. The extract was washed with water, dried over sodium sulfate and finally concentrated. Yield: 0.4 g;

Workup

  1. extractionThe aqueous phase was subsequently extracted with 100 ml of diethyl ether
  2. washThe extract was washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationfinally concentrated

Sources & evidence

ORD record
ord-2af505a9f40a44b8ad2eeb5c1aceea1f
Source dataset
uspto-grants-2002_09
Patent number
US06451734B1

Reaction notes

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