反应详情

温度

5 °C

To a solution of the crude N-tert-butoxycarbonyl-3(S)-amino-2(R)-hydroxy-4-phenyl-1-butanol obtained in Reference Example 3 and dissolved in ethyl acetate 250 kg were added isopropylether 230 kg, methane sulfonylchloride 34.7 kg at 20-30° C., and triethylamine 30.6 kg and stirring at 30-40° C. for 1 hr. N-heptane was added to the reaction solution and the obtained solution was cooled down to 5° C. or lower to deposit crystals, which were filtered by centrifugation to obtain a wet crystal of crude N-tert-butoxycarbonyl-3(S)-amino-2(R)-hydroxy-4-phenyl-1-methane sulfonyloxybutane 153.6 kg (Net.60.6 kg).

1. filtrationwere filtered by centrifugation