1-Methylpiperazine → HCID 18422197, compound

HRID 1281808Notes

Reaction equation

HRID 1281808 reaction equation
[CH3:1][N:2]([C:12]1[S:16][C:15]2[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=2[C:13]=1[C:21](OCC)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N+:9]([O-])=O.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>[Ti](Cl)(Cl)(Cl)Cl.C1(OC)C=CC=CC=1>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:9]=[C:21]([N:30]2[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]2)[C:13]2[C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[S:16][C:12]1=2

Participants

5

Reactant 2

HCID 531671-MethylpiperazineHCID 18422373HCID 18422373, compound

Product 1

HCID 18422197HCID 18422197, compound

Reagents, catalysts & solvents 2

HCID 24193Titanium TetrachlorideCatalystHCID 7519AnisoleSolvent

Procedure

In the same manner as in Example 1 and using ethyl 2-(N-methyl-2-nitroanilino)benzo[b]thiophene-3-carboxylate (3.2 g), 1-methylpiperazine, anisole (80 ml) and titanium tetrachloride (3.5 ml), 6-methyl-12-(4-methylpiperazin-1-yl)[1]benzothieno[2,3-b][1,5]benzodiazepine (166 mg) was obtained.

Sources & evidence

ORD record
ord-5dc06eb1e9a84c8fa48a98c93b5818fa
Source dataset
uspto-grants-2002_09
Patent number
US06455521B1

Reaction notes

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