Benzyl Bromide → HCID 15029957, compound

HRID 1282247Notes

Reaction equation

HRID 1282247 reaction equation
[OH:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:14].[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:15]([O:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:14])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 218627235-Hydroxy-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

Product 1

HCID 15029957HCID 15029957, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Using a procedure analogous to Example 7 from 4.5 g (0.024 mole) of 5-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.031 mole) of benzyl bromide and 10 g (0.072 mole of K2CO3 in 100 ml of acetone), the title product was obtained (5.13 g) as a white solid by crystallization with ether, mp. 90° C.

Sources & evidence

ORD record
ord-e48ac64e28b54d11a6aa3f2c9e11b118
Source dataset
uspto-grants-2002_09
Patent number
US06455572B1

Reaction notes

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