反应详情

To a stirred solution of L-lysine dihydrochloride (1 mmol) in a mixture of THF and 1M K2CO3 (3 mL/3 mL) was added 4-methylbenzenesulfonyl chloride (381 mg, 2.00 mmol). The reaction mixture was stirred for 2 h and then quenched with 1N HCl and extracted twice with EtOAc. The combined organic extracts were dried over MgSO4 and concentrated. The crude was purified by flash chromatography using hexane/EtOAc/AcOH (30:69.4/0.6) to give 75% of the desired product.

1. customquenched with 1N HCl
2. extractionextracted twice with EtOAc
3. dry with materialThe combined organic extracts were dried over MgSO4
4. concentrationconcentrated
5. customThe crude was purified by flash chromatography