2-Amino-4-methylpyridine → HCID 20158102, compound

HRID 1282725Notes

Reaction equation

HRID 1282725 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8][C:9]#[CH:10])=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:5][C:4](=O)[CH:3]=1.Cl.[NH2:19][OH:20].NC1C=C(C)C=CN=1>>[OH:20][N:19]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:7]([CH2:8][C:9]#[CH:10])[C:2]([CH3:1])=[CH:3][C:4]1=[O:5]

Participants

4

Reactant 3

HCID 15332-Amino-4-methylpyridineHCID 443297Hydroxyamine hydrochlorideHCID 21520173HCID 21520173, compound

Product 1

HCID 20158102HCID 20158102, compoundYield 76.9%

Procedure

1 g of 4-methyl-5-propargyl-6-phenyl-2-pyrone, 1.5 g of hydroxylamine hydrochloride and 3 g of 2-amino-4-methyl-pyridine were heated for 9 hours to 80° C. After the usual working up, there were obtained 0.82 g (77 %) of 1-hydroxy-4-methyl-5-propargyl-6-phenyl-2-pyridone melting at 200° C (Calc.: 5.9 % N, found: 5.8 % N).

Sources & evidence

ORD record
ord-dc578d6ecfb74089b0a5651e865707cd
Source dataset
uspto-grants-1976_08
Patent number
US03972888

Reaction notes

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