Chloroform → HCID 12462519, compound

HRID 1283026Notes

Reaction equation

HRID 1283026 reaction equation
[O:1]=[C:2]1[NH:6][CH2:5][CH2:4][NH:3]1.[C:7]1([S:13](Cl)(=[O:15])=[O:14])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O1CCCC1.C(Cl)(Cl)Cl>C(N(CC)CC)C>[C:7]1([S:13]([N:3]2[CH2:4][CH2:5][NH:6][C:2]2=[O:1])(=[O:15])=[O:14])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

6

Reactant 4

HCID 6212ChloroformHCID 7369Benzenesulfonyl chlorideHCID 8028TetrahydrofuranHCID 84532-Imidazolidinone

Product 1

HCID 12462519HCID 12462519, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

86 parts by weight of 2-oxo-imidazolidine, 194 parts by weight of benzenesulphonyl chloride, 800 parts by volume of tetrahydrofurane, 500 parts by volume of chloroform and 101 parts by weight of triethylamine were stirred overnight at 50°C and subsequently evaporated to dryness in vacuo. The residue was gradually added, while stirring, to 1,000 parts by volume of ice water, the mixture was filtered and the residue was recrystallized from ethanol.

Workup

  1. customsubsequently evaporated to dryness in vacuo
  2. additionThe residue was gradually added
  3. filtrationthe mixture was filtered
  4. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-bf91e28f703c47889060dd0bb0254783
Source dataset
uspto-grants-1976_08
Patent number
US03974141

Reaction notes

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