Piperidine → HCID 54098213, compound

HRID 1283077Notes

Reaction equation

HRID 1283077 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.CNC.[Na].[CH3:12][C:13]1[CH:14]=[CH:15][C:16]2[S:20][C:19]([C:21]3[CH:26]=[CH:25][C:24]([CH:27]=[CH:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[C:35](O)=[O:36])=[CH:23][CH:22]=3)=[CH:18][C:17]=2[CH:38]=1.[K].ClC1C=CC2OC(C3C=CC(C=CC4C=CC(C(O)=O)=CC=4)=CC=3)=CC=2C=1>>[CH3:12][C:13]1[CH:14]=[CH:15][C:16]2[S:20][C:19]([C:21]3[CH:22]=[CH:23][C:24]([CH:27]=[CH:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[C:35]([N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)=[O:36])=[CH:25][CH:26]=3)=[CH:18][C:17]=2[CH:38]=1

Participants

7

Reactant 6

HCID 8082PiperidineHCID 10473Dimethylamine, hydrochlorideHCID 5360545SodiumHCID 5462222PotassiumHCID 54143917HCID 54143917, compoundHCID 54274606HCID 54274606, compound

Product 1

HCID 54098213HCID 54098213, compound

Procedure

When piperidine is substituted for the dimethylamine hydrochloride and the sodium salt of 5-methyl-2-[4-(2-carboxystyryl)phenyl]benzothiophene for the potassium salt of 5-chloro-2-[4-(4-carboxystyryl)phenyl]benzofuran in the procedure described in Example 29 above, there is obtained as the product 5-methyl-2-[4-(2-piperidinocarbonylstyryl)phenyl]benzothiophene.

Sources & evidence

ORD record
ord-701500e5587d430c919d318259ea2be1
Source dataset
uspto-grants-1976_08
Patent number
US03974144

Reaction notes

Loading…