Acetyl chloride → HCID 21519225, compound

HRID 1283135Notes

Reaction equation

HRID 1283135 reaction equation
[CH3:1][N:2]([CH3:18])[CH2:3][CH2:4][C:5]1([OH:17])[CH2:10][CH2:9][CH2:8][CH2:7][CH:6]1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:19](Cl)(=[O:21])[CH3:20].C(N(CC)CC)C.[CH:30]1([NH:36][S:37]([OH:40])(=[O:39])=[O:38])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>O1CCCC1>[CH:30]1([NH:36][S:37](=[O:38])(=[O:39])[OH:40])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1.[C:19]([O:17][C:5]1([CH2:4][CH2:3][N:2]([CH3:1])[CH3:18])[CH2:10][CH2:9][CH2:8][CH2:7][CH:6]1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)(=[O:21])[CH3:20]

Participants

6

Reactant 4

HCID 6367Acetyl chlorideHCID 7533CyclamateHCID 8471TriethylamineHCID 21519244HCID 21519244, compound

Product 1

HCID 21519225HCID 21519225, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The procedure of Example I (c) is followed using 7.5 g of 1-(2-Dimethylaminoethyl)-2-phenylcyclohexanol (Example XIV) and 8 ml of acetyl chloride with 18 ml triethylamine giving 11.8 g crude acetate which is treated with 12 g cyclohexanesulfamic acid in tetrahydrofuran to give 6.7 g pure product, m. 140°-1°.

Sources & evidence

ORD record
ord-423e237ddafd419685aa66d3d10b687c
Source dataset
uspto-grants-1976_08
Patent number
US03974157

Reaction notes

Loading…