Ethanol → HCID 21518477, compound

HRID 1283585Notes

Reaction equation

HRID 1283585 reaction equation
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=3)[CH:10]=[C:9](Cl)[N:8]=2)[CH2:3][CH2:2]1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.C([O-])(=O)/C=C\C([O-])=O.C(O)C>C1(OC2C=CC=CC=2)C=CC=CC=1>[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=3)[CH:10]=[C:9]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:8]=2)[CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 702EthanolHCID 4837PiperazineHCID 5288227Maleate(2-)HCID 21518474HCID 21518474, compound

Product 1

HCID 21518477HCID 21518477, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

1-Thiomorpholino-3-piperazino-7-chloro-isoquinoline was prepared analogous to Example 3 from 1-thiomorpholino-3,7-dichloro-isoquinoline and piperazine by heating in diphenyl ether at 200°C. M.p. of its maleate: 188°-190°C (from ethanol); yield: 85% of theory.

Sources & evidence

ORD record
ord-a672168e2c1a4cccbf0c07aad2db73aa
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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