Hydrochloric Acid → HCID 21518466, compound

HRID 1283588Notes

Reaction equation

HRID 1283588 reaction equation
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([N+:17]([O-:19])=[O:18])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9](Cl)[N:8]=2)[CH2:3][CH2:2]1.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.Cl.O>O1CCOCC1>[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([N+:17]([O-:19])=[O:18])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[N:8]=2)[CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 4837PiperazineHCID 21518467HCID 21518467, compound

Product 1

HCID 21518466HCID 21518466, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1-Thiomorpholino-3-piperazino-5-nitro-isoquinoline was prepared analogous to Example 3 from 1-thiomorpholino-3-chloro-5-nitro-isoquinoline by heating for 5 hours with piperazine in dioxane at 100°C. M.p. of its hydrochloride: 245°-247°C (from water); yield: 53% of theory.

Sources & evidence

ORD record
ord-32c80f7c88884849b2806f5a045162f3
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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