Hydrogen Peroxide → HCID 54479703, compound

HRID 1283590Notes

Reaction equation

HRID 1283590 reaction equation
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([Cl:17])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:8]=2)[CH2:3][CH2:2]1.OO.C([OH:29])CC>S(=O)(=O)(O)O>[O:29]=[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([Cl:17])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:8]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 10311-PropanolHCID 21518480HCID 21518480, compound

Product 1

HCID 54479703HCID 54479703, compoundYield 31%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

1-(1-Oxido-thiomorpholino)-3-piperazino-5-chloro-isoquinoline was prepared analogous to Example 12 from 1-thiomorpholino-3-piperazino-5-chloro-isoquinoline in dilute sulfuric acid by oxidation with hydrogen peroxide. M.p. 215°-217°C (from n-propanol); yield: 31% of theory.

Sources & evidence

ORD record
ord-97f77a119f3640c3bbb8ffe52d19d014
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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