Hydrogen Peroxide → HCID 54292749, compound

HRID 1283594Notes

Reaction equation

HRID 1283594 reaction equation
Cl.[S:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:17]3[C:12](=[C:13]([N+:18]([O-:20])=[O:19])[CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[N:9]=2)[CH2:4][CH2:3]1.OO.C([O-])(=O)/C=C\C([O-])=[O:33].C(O)(C)C>S(=O)(=O)(O)O>[O:33]=[S:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:17]3[C:12](=[C:13]([N+:18]([O-:20])=[O:19])[CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[N:9]=2)[CH2:4][CH2:3]1

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 3776IsopropanolHCID 5288227Maleate(2-)HCID 21518484HCID 21518484, compound

Product 1

HCID 54292749HCID 54292749, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

1-(1-Oxido-thiomorpholino)-3-piperazino-5-nitro-isoquinoline was prepared analogous to Example 12 from 1-thiomorpholino-3-piperazino-5-nitro-isoquinoline hydrochloride by oxidation with hydrogen peroxide in dilute sulfuric acid. M.p. of its maleate: 231°-233°C (from isopropanol). Yield: 41% of theory.

Sources & evidence

ORD record
ord-ef4ab6a10e6f4881826bf1ded8f03bc5
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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