反应详情

温度

100 °C

A mixture of 2-chloro-4-cyanophenol (2.15 g), 3-bromo-1-chloropropane (2.3 g), dimethylformamide (3 ml) and potassium carbonate (1.5 g) was heated at 100° C. for one hour. The inorganic salt was then filtered off and the solvent was distilled off. The residue was dissolved in chloroform, chromatographed on a column of silica gel (80 g), and eluted with a solution of petroleum ether-ethyl acetate (10:1) to give 3-(2-chloro-4-cyanophenoxy)propyl chloride as a colorless oil (3.06 g).

1. filtrationThe inorganic salt was then filtered off
2. distillationthe solvent was distilled off
3. dissolutionThe residue was dissolved in chloroform
4. customchromatographed on a column of silica gel (80 g)
5. washeluted with a solution of petroleum ether-ethyl acetate (10:1)