反应详情

A suspension of 7-chloroindoline-2,3-dione (15g.) and potassium carbonate (15 g.) in N,N-dimethylformamide (100 ml.) was stirred and treated with a solution of 4-bromo-2-fluorobenzyl bromide (24.7 g.) in chlorobenzene (100 ml.). The mixture was stirred at 90° C. for five hours, cooled to ambient temperature, and diluted with a mixture of water (500 ml.) and petrol ether (b.p 60°-80° C.) (500 ml). The aqueous phase was adjusted to pH3 with 10 M hydrochloric acid. The mixture obtained was separated by filtration. The solid obtained was washed with further petrol ether, then with water, and recrystallised from ethanol to give 1-(4-bromo-2-fluorobenzyl)-7- chloro-indoline-2,3-dione (15.5 g.), m.p. 164°-166° C.

1. stirringThe mixture was stirred at 90° C. for five hours
2. customThe mixture obtained
3. customwas separated by filtration
4. customThe solid obtained
5. washwas washed with further petrol ether
6. customwith water, and recrystallised from ethanol