Hydrochloric Acid → HCID 9860075, compound

HRID 128559Notes

Reaction equation

HRID 128559 reaction equation
[NH:1](C(OC(C)(C)C)=O)[CH2:2][C:3]([NH:5][C@H:6]([C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4].Cl>CCOC(C)=O>[NH2:1][CH2:2][C:3]([NH:5][C@H:6]([C:10]([O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 91977270HCID 91977270, compound

Product 1

HCID 9860075HCID 9860075, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 9.0 g (20.6 mmoles) oily Boc-Gly-Val-OBzl (SEQ ID NO.14) were added 250 ml 2.6M HCl in EtOAc. The mixture was stirred for 80 min. and taken to dryness Under reduced pressure. Following repeated additions of EtoAc and evaporation to dryness under reduced pressure HCl, Gly-Val-OBzl (SEQ ID NO.9) was isolated as a white powder, Yield 5.6 g (79%).

Workup

  1. customadditions of EtoAc and evaporation to dryness under reduced pressure HCl

Sources & evidence

ORD record
ord-3ae338f4064743da9bc1f73166759082
Source dataset
uspto-grants-1995_11
Patent number
US05464821

Reaction notes

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