3-Bromopyridine → Biphenyl

HRID 1286230Notes

Reaction equation

HRID 1286230 reaction equation
Brc1cccnc1.CC(C)(C)OC(N)=O>C1CCC2=NCCCN2CC1.CC(C)(C)[P](C(C)(C)C)(C(C)(C)C)->[Pd]1([Cl])<-[NH2]c2ccccc2-c2cccc[c]21.CS(C)=O>CC(C)(C)OC(=O)Nc1cccnc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 77922tert-Butyl carbamate

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 77922tert-Butyl carbamateHCID 109323213-(Boc-amino)pyridine

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 178454887HCID 178454887, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-68b0874503fd489684bcffc9d3416341
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

Loading…