1H-Indazole → Biphenyl

HRID 1286332Notes

Reaction equation

HRID 1286332 reaction equation
Brc1cccnc1.c1ccc2[nH]ncc2c1>C1CCC2=NCCCN2CC1.CC12CC3(C)OC(C)(CC(C)(O1)[P]3(c1ccccc1)->[Pd]1(<-[NH2]c3ccccc3-c3cccc[c]31)[O]S(C)(=O)=O)O2.CS(C)=O>c1cncc(-n2ncc3ccccc32)c1

Participants

9

Reactant 2

HCID 92211H-IndazoleHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 92211H-IndazoleHCID 122863-BromopyridineHCID 113560351H-Indazole, 1-(3-pyridinyl)-

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 178420943HCID 178420943, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-a583be2adbf94b1fadfcb04869cb22df
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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