1H-Indazole → Biphenyl

HRID 1286392Notes

Reaction equation

HRID 1286392 reaction equation
Brc1cccnc1.c1ccc2[nH]ncc2c1>C1CCC2=NCCCN2CC1.COc1ccc(C)c(-c2c(C(C)C)cc(C(C)C)cc2C(C)C)c1[P](C(C)(C)C)(C(C)(C)C)->[Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)[O]S(C)(=O)=O.CS(C)=O>c1cncc(-n2ncc3ccccc32)c1

Participants

9

Reactant 2

HCID 92211H-IndazoleHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 92211H-IndazoleHCID 122863-BromopyridineHCID 113560351H-Indazole, 1-(3-pyridinyl)-

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 178489984HCID 178489984, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-8dfff8b12cfa4f8eac77e3092376b062
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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