3-Bromopyridine → Biphenyl

HRID 1286416Notes

Reaction equation

HRID 1286416 reaction equation
Brc1cccnc1.OCCCc1ccccc1>C1CCC2=NCCCN2CC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c1cccc2[P](c1ccccc1)(c1ccccc1)->[Pd]1([Cl])<-[NH2]c2ccccc2-c2cccc[c]21.CS(C)=O>c1ccc(CCCOc2cccnc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 31234Benzenepropanol

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 31234BenzenepropanolHCID 97356607HCID 97356607, compound

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 178421999HCID 178421999, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-241b9f0b67f146d3b78f89c77fa994bd
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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